Well it's really hard for me to answer since I have never tried Guild Wars. I think WoW is overrated, it's a fine game but it doesn't offer many new things compared to other RPG:s
what is all this monthly fee talk? DDO is also going to be a monthly fee. so what do u do pay for the game and then have to pay to use it? thats not right ill say guild wars just because its newer, i have never played either