I would suggest that you perform a FULL virus scan with an updated software app to remove all viruses. Further ,, If one shows up during the scan, usually the antivirus company will provide a "utility" to remove the virus successfully.
You could go into the properties of your HD and make it Read only, however, that would cause YOU a headache if you wanted to make changes/moves/copies etc..
This is a difficult method to clear a virus?