ok as long as there is nothing in E drive you really want you should format it. if there is anything you want just stick it in C and format it obviousy something is wrong with it and nothing can be accessed. do a quick format much easier and basicly the same thing. then put what ever you like on there. you could make it your media drive with all you music, photos, video etc. on there or keep it bland whatever you choose.
just to make it 100% clear formating will cause you to loose ALL data on that drive. but NOT the c drive