I've been enjoying Mandriva, it's had alot of the software I've been looking for right off the bat. At least for a Home pc. On the business side I've really enjoyed SuSE 10.1. I had to tweak it a bit to recognize our Novell NetWare 4.11 installation, and from there it was a short hop to recognize the rest of the WinXP pro machines, but after that it has been a dream.
I can't say anything bad about debian or ubuntu, because I haven't used them.
I love Linspire, and I have gotton my grandparents hooked on it.