HijackThis log, please help

[ex_nihilo]

any help would be grateful

Logfile of Trend Micro HijackThis v2.0.2
Scan saved at 10:40:06 PM, on 4/30/2008
Platform: Windows XP SP3 (WinNT 5.01.2600)
MSIE: Internet Explorer v6.00 SP2 (6.00.2900.2180)
Boot mode: Safe mode with network support

Running processes:
C:\WINDOWS\System32\smss.exe
C:\WINDOWS\system32\winlogon.exe
C:\WINDOWS\system32\services.exe
C:\WINDOWS\system32\lsass.exe
C:\WINDOWS\system32\svchost.exe
C:\WINDOWS\system32\svchost.exe
C:\WINDOWS\Explorer.EXE
C:\Program Files\Trend Micro\HijackThis\HijackThis.exe
D:\Program Files\Mozilla Firefox\firefox.exe

R0 - HKCU\Software\Microsoft\Internet Explorer\Main,Start Page =
R0 - HKCU\Software\Microsoft\Internet Explorer\Main,Local Page =
R0 - HKCU\Software\Microsoft\Internet Explorer\Toolbar,LinksFolderName =
R3 - Default URLSearchHook is missing
O2 - BHO: Spybot-S&D IE Protection - {53707962-6F74-2D53-2644-206D7942484F} - D:\PROGRA~1\SPYBOT~1\SDHelper.dll
O2 - BHO: PCTools Site Guard - {5C8B2A36-3DB1-42A4-A3CB-D426709BBFEB} - D:\PROGRA~1\SPYWAR~2\tools\iesdsg.dll
O2 - BHO: PCTools Browser Monitor - {B56A7D7D-6927-48C8-A975-17DF180C71AC} - D:\PROGRA~1\SPYWAR~2\tools\iesdpb.dll
O4 - HKLM\..\Run: [avgnt] "D:\Program Files\Avira\AntiVir PersonalEdition Classic\avgnt.exe" /min
O4 - HKLM\..\Run: [COMODO Firewall Pro] "D:\Program Files\Comodo\Firewall\cfp.exe" -h
O4 - HKLM\..\Run: [BOC-426] D:\PROGRA~1\Comodo\CBOClean\BOC426.exe
O4 - HKLM\..\Run: [NvCplDaemon] RUNDLL32.EXE C:\WINDOWS\system32\NvCpl.dll,NvStartup
O4 - HKLM\..\Run: [MSConfig] C:\WINDOWS\PCHealth\HelpCtr\Binaries\MSConfig.exe /auto
O4 - HKUS\S-1-5-18\..\Run: [Spyware Doctor] (User 'SYSTEM')
O4 - HKUS\.DEFAULT\..\Run: [Spyware Doctor] (User 'Default user')
O9 - Extra button: Spyware Doctor - {2D663D1A-8670-49D9-A1A5-4C56B4E14E84} - D:\PROGRA~1\SPYWAR~2\tools\iesdpb.dll
O9 - Extra button: Research - {92780B25-18CC-41C8-B9BE-3C9C571A8263} - D:\PROGRA~1\MICROS~2\Office12\REFIEBAR.DLL
O9 - Extra button: (no name) - {DFB852A3-47F8-48C4-A200-58CAB36FD2A2} - D:\PROGRA~1\SPYBOT~1\SDHelper.dll
O9 - Extra 'Tools' menuitem: Spybot - Search & Destroy Configuration - {DFB852A3-47F8-48C4-A200-58CAB36FD2A2} - D:\PROGRA~1\SPYBOT~1\SDHelper.dll
O9 - Extra button: (no name) - {e2e2dd38-d088-4134-82b7-f2ba38496583} - C:\WINDOWS\Network Diagnostic\xpnetdiag.exe
O9 - Extra 'Tools' menuitem: @xpsp3res.dll,-20001 - {e2e2dd38-d088-4134-82b7-f2ba38496583} - C:\WINDOWS\Network Diagnostic\xpnetdiag.exe
O9 - Extra button: Messenger - {FB5F1910-F110-11d2-BB9E-00C04F795683} - D:\Program Files\Messenger\msmsgs.exe
O9 - Extra 'Tools' menuitem: Windows Messenger - {FB5F1910-F110-11d2-BB9E-00C04F795683} - D:\Program Files\Messenger\msmsgs.exe
O20 - AppInit_DLLs: C:\WINDOWS\system32\guard32.dll
O23 - Service: Avira AntiVir Personal – Free Antivirus Scheduler (AntiVirScheduler) - Avira GmbH - D:\Program Files\Avira\AntiVir PersonalEdition Classic\sched.exe
O23 - Service: Avira AntiVir Personal – Free Antivirus Guard (AntiVirService) - Avira GmbH - D:\Program Files\Avira\AntiVir PersonalEdition Classic\avguard.exe
O23 - Service: BOCore - COMODO - D:\Program Files\Comodo\CBOClean\BOCORE.exe
O23 - Service: COMODO Firewall Pro Helper Service (cmdAgent) - COMODO - D:\Program Files\Comodo\Firewall\cmdagent.exe
O23 - Service: NVIDIA Display Driver Service (NVSvc) - NVIDIA Corporation - C:\WINDOWS\system32\nvsvc32.exe
O23 - Service: TuneUp Drive Defrag Service (TuneUp.Defrag) - TuneUp Software GmbH - C:\WINDOWS\System32\TuneUpDefragService.exe

--
End of file - 3538 bytes

 

[Osiris]

Remove these entries

O4 - HKUS\S-1-5-18\..\Run: [Spyware Doctor] (User 'SYSTEM')

O4 - HKUS\.DEFAULT\..\Run: [Spyware Doctor] (User 'Default user')

R3 - Default URLSearchHook is missing