If money is not a problem for you, then I would go with a motherboard capable of running one of the new Intel Core Duo 2's. There extremely fast processors and stay retarded cool. If you're trying to get the bang for your buck, go with an Asus A8N32 Sli capable motherboard, with maybe an Athlon 64 3800+ or possibly even dual core. AMDs are simple to overclock, so you can try that if your experienced.