I have both my CPU and my Video card overclocked and I run FEAR at the highest settings @ 1280x1024 - and on top of it, sometimes i'll host a private server of 6-8 players on the same PC... And I've never experienced any "graphic related issues..."
I've experienced getting owned by, "someone" a few hundred times, but other then that... it's all good....
that someone will go unmentioned, to keep his ego in check.