What would be the easiest way to setup a default profile for a few
thousand users and make sure that their profile is deleted from their
local machines at logoff.
A mandatory profile does not save any changes that a user may make during their logon session. When the user logs off, the profile reverts to the configuration that the administrator configured when the profile was created.
create a batch file that deletes the local folder in documents and settings. make use of the %username% environmental variable. open gpedit.msc, open user config, open scripts, open logoff, add the batch file.