Yes you can install the block on your motherboard.
The installation of the radiator might be the hardest if your option is to put it inside. I would imagine you would have to drill a few holes unless you have a Xaser#### case.
For installing the Pump/resivoir you can get a few adhesive velcro strips and attach them to the bottom of your case, this will keep them in place and get rid of vbrations that cause noise.
The tubes are taken care of, looks like they have quick connect fittings, that means you can just pop them in without worrying about leaks.
Just for kicks I would put in a UV 12in Cathode since the tubes and liquid are UV sensitive. That would look SICK!!!