Yes, almost all if not all of the connectors you will have to plug in only have one way to go into the socket. Like a Molex power connector doesn't fin into a socket that only has 3 pins.
The wiring is more of a hassle than a problem. Really what you have to do is:
Plug the Mobo came into the mobo
Plug the CPU power into the Mobo
Plug the Hard drive power and the sata cable to the mobo
Connect the Moles connector to the DVD drive, then the Huge hateful Ribbon of which I forgot the name to the Mobo
Plug videocard Power in
Then the one thing you will probably have to look at the manual is for the lights for the front if the case, the Harddrive light and the Power light and such for the case.
Then remember to turn on the Power supply and to plug it in. I shamefully forgot to turn it on. -.-