Do you use the device "speakers", and does it hurt to always use the device "audio card"?
If respectively no and yes, then right click on the speaker's icon on the task bar (next to the clock and date), choose "playback devices" and disable all sound devices you don't need and only leave your "audio card".
Try it, it won't hurt. You can re-enable what you disabled by a right click then "show disabled devices".
Did you try changing the compatibility setting for it to something specific above Win98/ME?
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I found out, and opposite to what the Media Creation Tool says, that running the ISO inside Windows does not ask for a key, and it did give the option to do a fresh install deleting everything. I however did that inside an upgraded Windows 10. Right now I'm doing it on another computer but this time on a not yet upgraded Windows 7. It is about 25% done now and no key was requested. Installing this way, it is still saying upgrading. I'll update with the results once it is done.
A boot fresh install is always better, I believe, but it is just the product key issue that's a source of worrying.
Further to my above post, downloading the ISO once could save you future troubles of re-installing. Just make sure of the edition and version of Windows matching your current Windows; e.g. Win10 Pro x64.