I have never been able to get a 16bit app to work in windows 10 x64...That depends 100% entirely on the game. AFAIK 16bit apps won't work in W10 x64. I'm a retro guy, so if you're trying a specific game I might know if it'll work or not, or how to get it to work.
Edit: Actually just checked, 16bit apps are not supported as x64 W10 lacks the subsystem. x86 W10 on the other hand you can add the 16bit subsystem back in.
What do you play? Anything star wars, like jedi knight?I have a collection of old games from the early 90s id like to run whenever I so desire without having to use any other program like dosbox.
Not sure why 16 bit subsystem is not in 64 bit versions of windows 10 except the normal obsolescence Microsoft is known for.
In fact the subsystem could be added but only used when a game requiring it is started and terminated when the game is terminated.
You can run a lot of older games on a 32 bit version of windows 10 on almost any computer, i got some of mine working in 1080p until the PSU blew on my "retro" i3 560 rig (That thing was a piece of junk) now i just have to get around to installing 32 bit windows 10 on my "new" (i5 2xxx, GT 220) retro rigAFAIK it's a more native focus on 64bit rather than slapped together support from previous OS's. 32bit mode is emulated via WOW64 and the processes are isolated from the 64bit environment. 16bit would be an emulation on top of an emulation.
Some games can simply be run, the majority require work to get running. If you're not willing to put some work into getting the games going then I suggest sticking to an XP machine for these specific games. Some games have modern modifications to enable more modern features including run natively in a modern OS. One such example being Descent which a team has made a thing called DX Rebirth that enables native playing with modern resolutions. Games like Mechwarrior 2/3 require fiddling with programs like Dgvoodoo or Dxwnd. If you're looking for an install and go kind of situation then W10 is not the answer for these titles. Best I can say is try it and if it doesn't work then time to build a retro box like a lot of us have done.