well the best thing i do for a troubled mouse.
if it's an optical mouse : check the batteries
if it's a regular mouse : try taking out the ball from it and gently cleaning it, then clean the inside chamber area where the ball sits.
next if that don't work : just un-install the driver for it in devise manager, then reboot.
when widows loads back up, it will re-install the driver for you and should fix the problem.