yes its just usb or at least what it says on the site
im pretty sure it has to work..unless it has some type of firmware that makes it only work with macs
edit: i was reading reviews on newegg and they said it works with vista just the f1 and other f buttons i guess dont work unless you get a third party program..but i never use my f buttons anyways..and i dont game anymore so i definately wont use them..i just want something thin and goodlooking..and this is probably it!