The wave of viruses around 2000-2001 were incredibly nasty to deal with, especially in rapid succession. The biggest jump in creative virus nastiness was Stuxnet.
Actually, the depressing answer is that worst virus ever doesn't exist yet. Virus authors are like any authors of any software: they can improve on each other's existing work. New viruses can work like Stuxnet, except with fewer weaknesses on faster computers and larger numbers of with faster Internet connections, possibly attacking things that didn't used to be attackable online.
Actually, the depressing answer is that worst virus ever doesn't exist yet. Virus authors are like any authors of any software: they can improve on each other's existing work. New viruses can work like Stuxnet, except with fewer weaknesses on faster computers and larger numbers of with faster Internet connections, possibly attacking things that didn't used to be attackable online.