Yeah I tend to hear that - those who do email, browse the web, and play games are generally fine...but those of us who like to play with oh so many apps (old and new alike) run into grief.
As for MS
Office not working on x64, I highly doubt that... unless you have not updated the product itself?
My friend has run into a few troubles, but all were fix-able with the help of Google/Google Groups. So...if you're not having hardware issues, I'd try that...something like "windows 64 command conquer 3 64". You could also demand answers on their message board!
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