yeah your initial post isn't very clear...quite vague...and the followups are similar...
some setup programs to run and execute...
mainly has to do with all versions of irfanview...
1 of 2 things (highly summarized things)
1 - bad system, via brokens files, virii/malware corruption, massive file fragmentation
2 - corrupt files, could be your downloads are corrupted. What other setup programs are there that you encounter this?
Irfanview...I have used this through seveal versions...I forget what numbers...but all have worked for me...across something like 10 pcs.
Do some narrowing down - take these same files and see if they execute normally on other computers (if you have access)
Redownload from another computer
Do a chkdsk/scandisk.
On a whim...sometimes those MS error reports give you back some pinpoint data...not sure if you're lucky enough. I've had such luck and I love it.