Well most popups are to do with spyware installed on your computer so if you havent already got some spyware cleaners/removers you should get them and that should help your problem. You will alwasy be unable to block a few popups but that is only on dodgey sites.
Here r some spyware removers. Download, update and run them a cuople times and that should help. http://www.ccleaner.com/ccdownload.asp