Sorry to sound harsh, but when the error message specifically states:
To run this Application, you must first install the following:
.NET 4.0
What do you think the fix to the error is going to be? I mean your asking us to read your picture and tell you exactly the same thing it does. I dont get what else you could possibly be asking for. It says everything right within the error message on how to fix said error and move on the way.