Okay, here's the story:
I installed a new CD burner in an employee's machine, while logged on as the local admin for the box.
Everything was great. The software and hardware performed perfectly.
Logging off as local admin and logging back on as myself (a domain network login) or as the employee (also a domain login), I go and try to run the burner software. I get the following result:
I have examined the registry permissions and they are all in order.