Theres just several things I do. First is diable everything is msconfig
Run msconfig cleanup to delete the reg entries which is faste than using the registry.
Then I delete the prefetch folder
Stop the process of the spyware in taskmanager
Check program files folder
Check add/remove programs
Delete cookies and TIF's
Run these programs:
Adaware SE Pro 1.6
Spybot Search & Destroy 1.4
Microsoft Antispyware Beta
I run all of those in that order
The I reboot into safemode
Run all of those programs again, remove anything it finds
Reboot and rescan again
Then scan with hijackthis! again and look it over and delete anything I see needs deleted.
There are also hidden files that need to be checked especially in the application data folder which is hidden, the root of C, htm files, etc
Then run CCleaner because when you remove something, they always leave something behind and that usually removes most of it...