Ghosting your machine, if it's win2k or XP shouldn't be that much of a problem. I do it all the time. The only problem you might run into is if office was installed to a different drive, or any program for that matter. You need to have a physical setup simular to your old machine. IE, C drive, not another letter...
When you boot up, you will have a bunch of new hardware found, and might need to reactivate (XP only). Best thing to do, is uninstall all your device drivers before ghosting, and then capture the machine, so that there are not old drivers trying to run on the new machine. Then update the drivers. You shouldn't have too many problems with this. It's not the best way, but it works.
Good luck to you.