NTFS is a much more robust file system. For instance, if I suddenly lose power to my PC, I am less likely to have serious errors under an NTFS system than under a FAT32 system. In addition, NTFS systems generally run noticably faster vs. FAT32 systems on WinNT based OS's. Unless you are wanting to dual boot with Windows 98 or something, there is no reason you would want to choose FAT32.