What I did to my PC:
(dividing the 36GB WD Raptor)
C: WindowsXP (FAT32) 8GB
D: Software for WindowsXP FAT32 (13GB)
E: Combined Word out of WinXP and Win2K FAT32 (13GB)
Seagate Barracuda 120GB
C: Win2K 8GB FAT32
other partitions not mentioneing
I havent installed anything except system/shared files out of softwares on C, else eveything on E:.
if you arent on LAN, better is to do on FAT32, NTFS is a bit slower. else, once a month (as ikf required) Defragmant your hard drivers as well (though I havent as I didnt asked for). still my PC boots XP in 7 seconds.
Intel Core2Quad 2.66Ghz 12MB L2-Cache
4096MB DDR Kingston Hyper-X
XFX 9600GT AlphaDog
Seagate 2 X 320GB SATA2
LG L246WH Flatron 24"