all depends...I often check my mobo site and read up on any new quirks that may or may not appear...hence available new bioses.
I think the winfast 61508kmd should be 6150k8md..i'ts minor
just as an OS can work perfectly in a default vanilla setting, adding hardware or software can potentially interfere with it...same holds true for a mobo.
My system, based off of intels975xbx, from intel and using Vista Ultimate...no issues.
edit: have you also tried booting into safe mode? if so, is it able to or not?