Hmm.. Nero... I believe Nero and things like CloneCD create a virtual drive even after uninstalling. This might be causing a few problems. I dont know why it would, but its just a guess. Also try this. I'm assuming you cant access cd's either, as it sounds just popping in a cd locks everything up. So, put in a cd with the shift key held down. It'll disable autorun (I think its the shift key...). Then, open my computer. See if it locks up JUST going into my computer (refreshing the drives). If not, then right click the cd drive and click browse/explore. See if you can explore it. If you can then try to launch a simple text file. Then launch a prgrm. This wont fix anything, but may tell us whats going on. Also, what does event viewer show? Finally try disabling DMA on the CDRom then and see what happens. It'll be slow, but its a start.