I had the same problem with this card(well kinda, i have the 4400)
I figured out that it wont really work properly with the nvidia reference drivers. Try the ones that came with it or some newer ones from MSI's site. Remember to remove the old drivers before installing new ones. Also check the MSI Clock tab in display properties, and make sure its the right speed for your card. Mine somehow managed to set itself to 600+ mhz GPU, and obviously nothing worked right.