oh...you mean Electro Static Discharge?
Yeah...ESD is probably the only concern. Be sure to ground yourself by either operating on your PC on a anti-static mat, wearing an anti-static wrist band or simply by keeping hold of the computer case while working on the insides- this only works when your PC is plugged to a power outlet, but the mains turned off.
Also, try to avoid touching any metal contacts (such as on the circuit boards, pins and plugs etc...).
You should also meake sure that any components which are taken out of your PC should be placed on a non-static surface. Such as an anti-static bag.
|Desktop PC| |Macbook Air 13" (Mid 2013)|
|Windows 8.1 Pro (x64)| |AMD FX 4100 Black Edition 3.6 GHz @ 4.0 GHz OC| |Arctic Cooling Freezer 13 PRO| |Gigabyte Nvidia GeForce GTX 560 Super Overclock 1GB| |ASUS M5A78L-M/USB3 Motherboard| |Samsung 840 Pro 256GB SSD SATA III HDD| |Kingston HyperX 8GB PC3-14900 DDR3-1866| |OCZ ModXStream Pro 700W Modular PSU| |NZXT Vulcan Micro ATX Case|