Originally posted by Satan666
Would inserting a video card wrong make that noise???
No, only things I can think it to be are hard drive(which would not only do it when a game is playing but all the time), power supply(would do it all the time like the hard drive), fan (which if its a case fan should be spinning all the time), or your CD drive (which makes the most sense but only if your putting in a CD to play the game).
CHeck those things and let us know how it goes.