Try setting your Keyboard and mouse support to OS in the BIOS setting. You should also have the latest service pack for your OS, this should fix many issue with USB devices and the controller.
What kind of speaker are you using? because this a 7.1 sound card. The larger ports that you are refering to is the S/PDIF in and out port. Used to transmit digital signals without having to convert it to analog. Most speaker don't support digital that's why you need a sound card that use analog signal. If you have a 7.1 speaker or 5.1 or 2.1, just simply match the color with the plug and port. Then of course go into Windows Device Manager to make sure the card is listed there and no error, verify you have your volume level is up or not muted. If you install the application for the sound card, verify that it is configured to recongize the speakers.