Not necissarily, one of my present drives has been in 3 different boxes already, each time it booted up like its always been in there.Give it a shot before you reformat. I wouldnt put in the data drive till you get everything else set up.
With all due respect John, I am the head of IT and I have it on good authority. If you type "Google" into Google, you can break the Internet. So please, no one try it, even for a joke.........It's not a laughing matter. You can break the Internet.