My percentage is still averaging around 50%
And is it Setpoint that is still taking up the largest chunk? I use a wireless Logitech mouse with my notebook and Setpoint is only using 6,800K. I can't imagine adding a keyboard would run it up to 160,000K. I might consider going out to Logitech
and download the latest drivers for your mouse and keyboard and see if that is better. Make sure you pick the one for your version of Windows, which I just realized we don't know what version that is! It is really important to ensure you use 64-bit drivers if running 64-bit Windows.
What is the percentage in Safe Mode?
Are you "sharing" any folders or printers? Or mapping any networked drives?
Then, since this is a new computer, I go back to what I said earlier and maybe this is an indexing issue. If you walk away for about an hour or so, or even over night, it might complete then settle down on it's own. And since this is new computer, what other programs have you installed? Indexing can be disabled, but if using Windows 7, it is greatly improved over past versions and I recommend keeping it enabled.
You might also check out the new version of Secunia PSI
to help ensure you are current. Note this new version is not compatible with IE9Beta - yet. If using IE9, download from the older version link on the same page.