The middle hard drive cage is removable, and you do not need it since there are four HD mounts in the bottom bay. Anyone who got more than that in a gaming PC is nuts anyways.
The cabling is a bit tight, but with a well-done modular supply you can make it very spacious for air flow. I have to have my CPU wire hanging over my gfx card, but whatever. it works.
And also you can put a fan in the front that brings cool air directly to that hot burning 8800.
Here's a pic of my wiring job:
As you can see, there is plenty of room for the extra length of the 8800 gtx.