As long as you are using the correct type of RAM, and line up the notches and edges or the stick, then you will be fine.
As WorldIndustries, if your motherboard supports dual channel, and you are looking to set things up as such, then find out what slots correspond to each channel (it says so in the manual for your mobo).
Intel E6750...........PSN: ELBATROP
XFX nForce 650i Ultra
Patriot PC2-6400 8GB (4x2GB)
36GB WD Raptor
Samsung SyncMaster 931c
Samsung SyncMaster 750s
Windows 7 Home Premium 64