Or just use the CCleaner/Malwarebytes/Sybot S&D/Defraggler combo.
I don't really like Spybot anymore... it's much too slow and has only really found specific stuff for me. I've always been sticking to the ComboFix/HJT/MBAM/MSE scan when I encounter a bad infection lol.
Defraggler on 7 isn't very crucial either, since 7 defrags in the background, IIRC.