didnt quote flash for some reason... oh well.
Recommend to just do the main quests and worry about completely finishing all the sidequests in the 2nd playthrough. Better loot, harder enemies and much more challenging.
I disagree - the XP from those quests is invaluable to your skill tree. It will be far less valuable in the second playthrough because 10k XP just won't be that much compared to what it takes to level up.