yea i play many instruments, and im in charge of all the recording and mixing for my band.
my setup is rather complicated as my goal is sound quality, not necessarily ease of use. But what I described for you is both easy and can sound pretty good.
--my setup--
I have a 6-channel mixer with Phantom Power, and a rackmount fx rig going out of the aux send and into the aux return of the mixer. any instrument or mic input on the mixer can use any of the fx at any level. all of this goes into an external Sound Blaster Extigy. that connects to my pc via USB (wish it was firewire) and is output to a pair of 100-watt studio monitors powered by a 200w stereo amp.
i also use a rackmount multiband sound enhancer that can be used inbetween of the mixer and sound card (for recording) or the sound card and stereo (for music playback).
also, there's a mic tube preamp that's useful for its features and not necessarily with microphones. it has a compressor, de-esser, tube drive, noise gate, and other bells and whistles that can come in handy.
on my computer, I use Cakewalk Pro Audio 8. Kinda old, and I need to upgrade, but it does the job nicely with lots of plugins.
if you ever have any recording questions though, PM me.