Preventing damage while still raising the vcore is easy, just make sure your temperture stays less than 60 under load. You don't increase it when your computer boots into Windows successfully and runs prime95 successfully.
Also, if I get the blue screen that says everything had to be shut down to protect windows blah blah blah... do I generally need to increase, or decrease voltages, because it did it when my RAM voltage was on "AUTO" but didn't when I made it 2.65 V.
Because you have no idea what the BIOS is changing and when and where and how. It could be altering your vcore or memory timings while you are Windows, or playing a game or something and will most likely result in instability. Plus it most likely won't like going very high and you won't get nearly as much out of your overclock.
Imagine having something "automatically" driving your car for you. Well, that's my thoughts on a nonuser defined BIOS configuration. In all honesty, if you don't know what you are doing to a point where you are letting the BIOS do it for you, ya really shoudn't be doing it in the first place.