Well, the reason you have that option in game and out of game is because it will be different depending on what application/game you're running. Most new games will detect the best settings you should be using framerates, resolution, etc. I've found that most "optimal" settings may not be as smooth as you would like, so you may have to adjust them yourself.
There is no one setting that is the best for all systems; just adjust your specs so that you like what you see without compromising performance.
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