Most, if not all (all I have used is clockgen) do not have all the options. Typically software programs allow for upping FSB only. No vcore, vdimm, dividers, timings etc type adjustments needed to really complete a full 24/7 type OC.
Software programs have their place, primarily for a quick suicide shot or something. Typically you can get a little further for a *semi stable* OC to run a quick bench or something than you can get to actually boot Windows.