No different than setting up any other board really...install your basic drivers and then you may need to tweak things to get them to work well but that's what you'd expect with any board
The end user configurations and seemingly limitless BIOS settings may seem complicated but they really aren't and DFI has gone out of their way to make it quite user friendly...it's by far the easiest board I've ever overclocked with period...more options = more flexibility which is always easier to troubleshoot and configure IMO
Besides that dfi-street.com has rgone and angrygames who work for DFI and test and report/fix any bugs with the board...they've already covered about every FAQ known to man there and anything else you simply have to ask about and you'll get an answer