I dont see why it would be harder to set up than any other mobo.
@DJ-CHRIS: Because I have friends who own the board, and have used it to overclock. While overclocked, stability was not an issue. Plus I have an ASUS mobo myself.
The only reason I recommend it is because I have seen it in action. I havent used the DFI mobos, or seen them used first-hand. I am not saying one is better than the other, just what I personally like.