What matters most in a GPU?

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Hi guys, so I'm looking at the Palit GTX 660Ti which costs £215 And the MSI GeForce GTX 660 which is £180, There's a significant difference between the Clock cores and stuff, The MSI GTX 660 Having at least 200 more MHz base/boost clocks, but like 300 less Cuda Cores, what matters most?
 
Will do thanks :) Seeing as the graphics card is overclocked, providing I Find out how to put it on overclocked wouldn't it just make sense to keep it on overclocked 24/7? I'll buy a Few extra 120mm Fans so it remains cool, wouldn't that make sense though?
 
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