Rarely the board these days that have issues with RAM, it's making sure your memory can be powered and used by your memory controller, which is in your CPU. Motherboards just provide the slot, and path to the CPU along with voltage, nothing more these days with it comes to the basics of how a motherboard it self handles RAM.
What are your system specs exactly? I remember us having a member here recently that had memory that was compatible with his board, but due to CPU limitations with all the modules he had, his system was acting strange. BTW, if you are using integrated video, it will mark a certain amount of your RAM as video memory, some systems do set amounts, some systems are percentage based.
I suggest putting your most recent system specs in your signature, or when asking for assistance, list all your system specs, model numbers of everything and so on.