Depends on what cards. If you're talking about crossfiring 2 4850 X2's, which I don't recommend doing, it won't be able to handle that. For $20 more (after rebate) you can get the 750w which will allow you to sli/crossfire all single gpu cards (i.e. not 4850/70 x2, gtx295
Ok, found a pretty good deal on another motherboard at Tigerdirect, with the 15% cash back. Will the Gigabyte GA-EX58-UD3R cause any problems in my build? Is it better or worse than the Asus P6T SE?