last year my mobo died in my gaming rig and I moved to a laptop. I used to keep my rig on 24/7, so when I got the laptop I did the same thing.
I guess its not goot for laptops, because I went thru 4 hard drives in about an 8 month span (of never turning it off).
HP recommended I turn it off (what do they know tho...)
With my new build, it will be turned off only when the power goes out =D