Re: Fallout 3 Crash to desktop - solution here
* SPOILERS *
I'm having the same CTD problems; however, I've run into a CTD issue that so far has triggered every time I have tried to enter the reactor chamber to vault 87 in either Murder Pass or The Great Chamber of Little Lamplight. It seems that something is affecting the actual room I'm trying to enter rather than just a random CTD. I've already taken into account the FFDshow settings [t..o..m] suggested, and it didn't work. I also tried repairing the .NET framework installation, and that didn't work either. I've patched my game as well, and nothing so far seems to have worked. I'm kind of scared that FO3 has done irreparable damage to my system from what saulysw found. I'm starting to wonder whether installing this game in the first place was a good idea, because it has been nothing but problems since I first booted it up.
If anyone has had this problem I described or knows something that might help, I'd really appreciate it. Here are my PC specs:
OS: Vista Ultimate x64 (SP1)
VIDEO: NVIDIA GeForce 880 GTS (Driver version 180.43)
CPU: Intel Core 2 Duo E4500 @ 2.20GHz, 2193 Mhz
Any other specs needed, let me know.