Yeah, mixing mem shouldn't be a problem. I know the ol' MBD's use to have a bad time with using different mem sizes (256 and 128 or something), especially old gateway systems. So I doubt that myself. Mixing 100 and 133 shouldn't be an issue, as the system will just defualt itself to the lowest setting. Now mixing something like ECC/Non ECC would be a no no. I do agree though, I think the slot is defective OR the mem controller chip... either way, its gonna be a rpl of the MBD. However, just maybe some of the other stuff will fix it somehow if he's worried about saving money. I also dont think a BIOS flash would do it, either, but you never know. I've seen before where I said "well, that wont do a thing because they're independent of each other" and then get proven wrong! lol, supposedly things that are impossible to happen or an impossible solution always tends to creap up on me (DOS loop in XP????! How the hell does THAT happen!!)