Well, I run 64 bit, An yes there is a lack of driver's, But if you do your homework before you buy, An see if the brand's of the hardware you want in your pc has 64 Bit driver's out, Why not? All mine did. All but for my sound card, Since they only had Beta driver's out for it right now but give it time. 64 bit will be just as common as any other.
If you want 64bit processing wait for a while and get windows xp 64bit. Much much better than vista 64bit right now, only because they have alot more support.